Grim Fandango can be a bit persnickety about running smoothly on your system. A few suggestions:

1. In WinXP it may help to run the game in Windows 95 or 98 compatibility mode, but some have reported this isn’t necessary.
2. An official patch for the game should be installed. It’s available here.
3. Instructions for running the game under Windows Vista are available here. I don’t have Vista, so I can’t confirm this, but maybe someone who does can comment.
4. The game will not run on a Mac in OS X.
5. I’ve had success in Linux with Ubuntu and the latest 1.0 build of Wine (not the Ubuntu version).

If you experience problems, let us know here and perhaps someone can help. We’re a club, right? That’s how we roll